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High-Throughput Screening (HTS) Core

Overview of Services

The High-throughput Screening (HTS) Core provides the Perelman School of Medicine community with professional HTS screening services to identify genes or organic small molecule modulators of signaling pathways, cellular phenotypes, and protein function in models of human disease.


Core staff will educate and assist scientists with HTS assay development, optimization, miniaturization, and validation; maintain libraries of siRNA, shRNA, cDNA, and FDA approved/FDA-like organic small molecule libraries for HTS; and provide robotics infrastructure and technically trained staff for HTS, including small screens of user defined libraries. Core staff can also run validated HTS assays.


The High-throughput Screening core also provides direct assistance with preparation of grant applications by drafting experimental designs approaches and providing Letters of Support, offering HTS resources and analysis expertise for the proposed research.


Available Libraries


  • Silencer Select (Ambion) Human genome siRNA library
  • Custom human and Mouse siRNA libraries
  • MirVana (Ambion) human miRNA mimics and antagomers
  • Human lncRNA (Ambion) siRNA library
  • Human (complete) and mouse (V1.0) TRC lentiviral shRNA libraries


  • Selleckchem Bioactive: 2100 FDA-approved/FDA-like small molecules
  • LOPAC 1280: Library of Pharmacologically Active Compounds
  • Microsource Purified Natural Products (800)
  • ChemDiv SMART Library (12,000)
  • Chembridge Core Set (32,000)

Research Resource Identifier (RRID)

Our RRID is: RRID:SCR_022379.  Please cite us using this identifer when publishing your results. 


Sara Cherry, Scientific Director, Professor of Pathology and Laboratory Medicine

David C. Schultz, Technical Director, Adjunct Professor of Biochemistry and Biophysics


Location and hours of operation

Hours Staffed: Location:

Monday - Friday

9:00 AM - 5:00 PM      

3620 Hamilton Walk

67 John Morgan Building

Philadelphia, PA 19104


Links and Resources

UPenn Website High-Throughput Screening Core



Name Role Phone Email Location
Sara Cherry
Scientific Director



David C. Schultz
Technical Director
67 John Morgan Building