Overview of Services

The High-throughput Screening (HTS) Core provides the Perelman School of Medicine community with professional HTS screening services to identify genes or organic small molecule modulators of signaling pathways, cellular phenotypes, and protein function in models of human disease.

Core staff will educate and assist scientists with HTS assay development, optimization, miniaturization, and validation; maintain libraries of siRNA, shRNA, cDNA, and FDA approved/FDA-like organic small molecule libraries for HTS; and provide robotics infrastructure and technically trained staff for HTS, including small screens of user defined libraries. Core staff can also run validated HTS assays.

The High-throughput Screening core also provides direct assistance with preparation of grant applications by drafting experimental designs approaches and providing Letters of Support, offering HTS resources and analysis expertise for the proposed research.

Available Libraries

Genetic:

• Silencer Select (Ambion) Human genome siRNA library
• Custom human and Mouse siRNA libraries
• MirVana (Ambion) human miRNA mimics and antagomers
• Human lncRNA (Ambion) siRNA library
• Human (complete) and mouse (V1.0) TRC lentiviral shRNA libraries

Chemical:

• Selleckchem Bioactive: 2100 FDA-approved/FDA-like small molecules
• LOPAC 1280: Library of Pharmacologically Active Compounds
• Microsource Purified Natural Products (800)
• ChemDiv SMART Library (12,000)
• Chembridge Core Set (32,000)

Leadership

Sara Cherry, Scientific Director, Professor of Microbiology

David C. Schultz, Technical Director

Location and hours of operation

Links and Resources

UPenn Website High-Throughput Screening Core

Contacts

Map