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Stem Cell and Xenograft Core

Overview of Services

The Stem Cell and Xenograft Core (SCXC) is a comprehensive resource that integrates:
a full range of murine in-vivo xenograft services + a viable tissue bank of normal human hematopoietic cells and hematopoietic malignancies.


The SCXC offers a wide variety of xenograft services from training to full-service experiments.
The Core maintains a large breeding colony of immune-deficient (NSG) mice for users' xenograft studies. We also offer humanized immune system NSG mice for a wide variety of studies ranging from gene therapy to HIV. Experimental animals are housed in a dedicated BSL-2 animal barrier space for severely immune deficient models. Currently established xenograft models include orthotopic tumor cell injections and renal capsule implantation, as well as normal human CD34 and leukemia engraftment, human iPS and ES-derived teratomas, and human skin grafting. We also offer access to a dedicated optical/fluorescence (IVIS Spectrum) imaging system located within the Core's BSL-2 space through our partnership with SAIF (Small Animal Imaging Facility).
For consultation or questions, please contact 


The SCXC is committed to facilitating and promoting translational research involving viable primary human hematopoietic tissues.
Our core offers adult whole bone marrow from healthy donors and umbilical cord blood. Mononuclear and CD34+ cells from normal bone marrow and cord blood are available, and other cell fractions can be provided by arrangement. We maintain a large tissue bank of cells from hematopoietic malignancies including AML, ALL, CML, MDS and MPDs. All samples are fully annotated and frozen as viable cells. We also offer access to an immunomagnetic cell sorter (Miltneyi AutoMacs). Expertise in primary human hematopoietic stem/progenitor and leukemic cell culture and manipulation is available.

Research Resource identifier (RRID)

Our RRID is RRID:SCR_010035. Please cite us using this identifier when publishing your results.



Tony Secreto, MS. - Associate Director, In-Vivo Services Coordinator

(215) 573-3705, fax:(215) 573-7049


Martin Carroll, MD. - Medical Director
(215) 573-5712, fax:(215) 573-7049 



Email for General Questions -


Joshua Glover, LAT - Sr. Research Specialist
(215) 573-3705, fax:(215) 573-7049


Derrick Dopkin, LATG - Research Specialist


Eric Balboa, LATG - Resource Technologist 


Estefhany Davidson - Resource Technologist


Gisela (Nikki) Brake-Sillá, M.F.A. - Project Manager
(215) 898-3974, fax:(215) 573-7049


Michele Arlotta - Business Administrator
(215) 898-9615, fax:(215) 573-8282



Location and hours of operation

Hours Location


Facility Hours: 24/7       

Staff Hours: 7am - 5pm

BRB II/III, 7th Floor 421 Curie Blvd.

University of Pennsylvania

Philadelphia, PA 19104-6160

Telephone:(215) 746-0181

Fax:(215) 573-8282


Click here to access map

Links and Resources



Name Role Phone Email Location
Michele Arlotta
Business Administrator
811 BRB

Service list

Search available services: View: by category alphabetically
Xenograft (2)
Tissue Bank - Healthy Donor (6)
Tissue Bank - Hematologic Malignancy Patient (2)