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(hide this warning on this page)The Stem Cell and Xenograft Core (SCXC) is a comprehensive resource that integrates:
a full range of murine in-vivo xenograft services + a viable tissue bank of normal human hematopoietic cells and hematopoietic malignancies.
The SCXC offers a wide variety of xenograft services from training to full-service experiments.
The Core maintains a large breeding colony of immune-deficient (NSG) mice for users' xenograft studies. We also offer humanized immune system NSG mice for a wide variety of studies ranging from gene therapy to HIV. Experimental animals are housed in a dedicated BSL-2 animal barrier space for severely immune deficient models. Currently established xenograft models include orthotopic tumor cell injections and renal capsule implantation, as well as normal human CD34 and leukemia engraftment, human iPS and ES-derived teratomas, and human skin grafting. We also offer access to a dedicated optical/fluorescence (IVIS Spectrum) imaging system located within the Core's BSL-2 space through our partnership with SAIF (Small Animal Imaging Facility).
For consultation or questions, please contact scxc@lists.upenn.edu
The SCXC is committed to facilitating and promoting translational research involving viable primary human hematopoietic tissues.
Our core offers adult whole bone marrow from healthy donors and umbilical cord blood. Mononuclear and CD34+ cells from normal bone marrow and cord blood are available, and other cell fractions can be provided by arrangement. We maintain a large tissue bank of cells from hematopoietic malignancies including AML, ALL, CML, MDS and MPDs. All samples are fully annotated and frozen as viable cells. We also offer access to an immunomagnetic cell sorter (Miltneyi AutoMacs). Expertise in primary human hematopoietic stem/progenitor and leukemic cell culture and manipulation is available.
Our RRID is RRID:SCR_010035. Please cite us using this identifier when publishing your results.
Tony Secreto, MS. - Associate Director, In-Vivo Services Coordinator
(215) 573-3705, fax:(215) 573-7049
asecreto@pennmedicine.upenn.edu
Martin Carroll, MD. - Medical Director
(215) 573-5712, fax:(215) 573-7049
carroll2@pennmedicine.upenn.edu
Email for General Questions - scxc@lists.upenn.edu
Joshua Glover, LAT - Sr. Research Specialist
(215) 573-3705, fax:(215) 573-7049
aglover@pennmedicine.upenn.edu
Derrick Dopkin, LATG - Research Specialist
ddopkin@pennmedicine.upenn.edu
Eric Balboa, LATG - Resource Technologist
balboae@pennmedicine.upenn.edu
Estefhany Davidson - Resource Technologist
estefhany.davidson@pennmedicine.upenn.edu
Gisela (Nikki) Brake-Sillá, M.F.A. - Project Manager
(215) 898-3974, fax:(215) 573-7049
gbrake@pennmedicine.upenn.edu
Michele Arlotta - Business Administrator
(215) 898-9615, fax:(215) 573-8282
michelea@pennmedicine.upenn.edu
Hours | Location |
Facility Hours: 24/7 Staff Hours: 7am - 5pm |
BRB II/III, 7th Floor 421 Curie Blvd. University of Pennsylvania Philadelphia, PA 19104-6160 Telephone:(215) 746-0181 Fax:(215) 573-8282
Click here to access map |
Name | Role | Phone | Location | |
---|---|---|---|---|
Michele Arlotta |
Business Administrator
|
215-898-9615
|
michelea@pennmedicine.upenn.edu
|
811 BRB
|
Service list |
► Xenograft (2) | |||
Name | Description | Price | |
---|---|---|---|
Animal Receiving |
Per crate (max 40 animals) |
Internal
$250.00
each
Academic (External) $375.00 each Corporate (External) $500.00 each |
|
Tissue Harvest, STERILE (bone marrow, spleen, cardiac blood) per animal |
Internal
$78.00
each
Academic (External) $117.00 each Corporate (External) $156.00 each |
||
► Tissue Bank - Healthy Donor (6) | |||
Name | Description | Price | |
Cord Blood CD34 Negs (per million) |
Internal
$5.00
each
Academic (External) $7.50 each Corporate (External) $10.00 each |
||
Cord Blood Mononuclear Cells (per million) |
Internal
$10.00
each
Academic (External) $12.50 each Corporate (External) $20.00 each |
||
Fresh CD34+ from Cord Blood ( per million) |
Internal
$550.00
each
Academic (External) $825.00 each Corporate (External) $1,100.00 each |
||
Fresh Cord Blood (per ml) |
Internal
$3.00
each
Academic (External) $4.50 each Corporate (External) $6.00 each |
||
Frozen CD34+ from Cord Blood ( per million) |
Internal
$635.00
each
Academic (External) $953.00 each Corporate (External) $1,270.00 each |
||
Receptor Enumeration (per sample) |
Internal
$43.00
each
Academic (External) $65.00 each Corporate (External) $86.00 each |
||
► Tissue Bank - Hematologic Malignancy Patient (2) | |||
Name | Description | Price | |
AML - Colony Forming Cell (CFC) Assay |
Internal
$110.00
plate
Academic (External) $176.00 plate Corporate (External) $220.00 plate |
||
Patient Specimen Fresh (PB or BM) per tube | Inquire |