Naturalized Mouse Core

Overview of Services

The Naturalized Mouse Core represents a branch of the Penn Gnotobiotics and Naturalized Mouse Core and provides services related to improving mouse models. While Gnotobiotics involves the use of germ-free mice to reduce and control the number of microbes that colonize the animals, Naturalization involves the use of “dirty mice” to mimic the microbial exposure experienced by free-living animals, including humans.

The Naturalized Mouse Core provides a self-contained animal facility in which investigators can utilize mice that harbor pathogenic infectious agents from the “real world”, such as pet shop mice or wild mice, or work with our trained staff to introduce defined cocktails of opportunistic pathogens. These techniques can improve the physiological relevance of mouse models by mimicking the immune function, metabolism, and behavior of wild mammals. 

Acknowledgement

Please acknowledge the "UPENN Gnotobiotic and Naturalized Mouse Core Facility" RRID:SCR_022384 when publishing your results.  Our RRID is: RRID:SCR_022384.  This is vitally important for the continued operation of the core.

Leadership

Ken Cadwell, PhD, Professor, University of Pennsylvania 
Core Director
Ken.Cadwell@Pennmedicine.upenn.edu

Dmytro Kobuley, Research Specialist C
Technical Director
(215) 573-0328
penngf@pennmedicine.upenn.edu

Location and hours of operation

Contacts